Huntington’s disease: towards paradigmatic molecular based treatment

Huntingtin and the molecular pathogenesis of Huntingtons disease

Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Conceptual Model Evaluation. Towards more Paradigmatic Rigor

Information Systems (IS) research has so far been primarily concerned with the development of new modeling languages, techniques, and methods. Also, evaluation approaches have been developed in order to assess the appropriateness of a modeling approach in a given context. Both modeling and evaluation approaches, however, lack epistemological rigor, leading to problems regarding the applicabilit...

Paradigmatic Treatment of Arabic Morphology

This paper 1 presents a language to express morphological processes, concatenative or nonconcatenative. The language allows the definition of two kinds of paradigms: helping paradigms, which define partial morphological forms, and main paradigms, which combine two or more helping paradigms to define fully specified forms. 1 I n t r o d u c t i o n This paper presents a language to express morph...

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease